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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43cae3dd701cd8c7e874a44bfb2eab0fa8ac8e2f74300d0835328bc6bd6d649f' 
  AND token = 'dB2En1UX4FZdYiFSGSNy779rIELqVVAlhOGboaD6FYM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}