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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '888d07cb295ecd644931dcd2d25d94e54492dd388012a6b37729bf3a16871c18' 
  AND token = 'UQ0vEw9w7Zy6bClQnUqOXeM35jDswHR9LLdtTFaPZMw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}