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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a0850e59cb69f735cdb957eeee804afc7bf8219eed2dbe7242493d835fe70e0' 
  AND token = 'u1q0MD+MFlp0n3STPMwvH9PTbkf6CpDjT1FMhUMJ5qg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}