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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '661a63e4e74436cb961adaeb9610341c1bbaa1c19ce2768ebb921712f5a229c2' 
  AND token = 'AM7ZCDNwFhEgz7s7gm+K1/QeiBV4hxyjKvWgFFUDr5A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}