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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '050e3c5a8c291e15a5f0e9f6cfe36315f71783166e60127d869669f1b50de41a' 
  AND token = '1+BtZ0VwEUWRyd/pJiDZXiUF5Dy/RKcF8DH+Il45zSA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}