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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e9e8ec7733bbb072440f7be8c04731b6d5608114f21195fe595bae2280fc111' 
  AND token = '07+vF1XIw+dvgVMOB71eDnqmT0mxqYSVVsnnia4heFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}