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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49475b3afafe1827abd7ef293acb9a278a5c757f4feaafd51f07fa15b52337fd' 
  AND token = '8Meb1Mv33Ol+3tUTykegry5wHyhLRi9JAGjn03aT2As=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}