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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '004221acf6f947b92dda02c4af5a765bf8fae7da2ce088ff151be14d60033f8b' 
  AND token = 'ADuGOz1AwViTpjS9Ywxo16erFsVR1r6UwYdaUgn/EpE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}