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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed649da581abc96ed5853f990feeec0dc39397f2179985a9368b4dd34b931f66' 
  AND token = 'pWO4S49/1LN7QsOgfILBT6VlOoTL0EwppkixW5P0Ua0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}