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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '726b97c8bd7c85bbb685786a3a0f66e509300f6fdf101c2fccd8c5c53609183a' 
  AND token = 'V+9sWGJDbMoOxYFAWZLNr2it6pRSSgtJjImDmLMC2/I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}