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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '418ce2cd5a8347744e8af785315b7069615c7e174a4e66002d51b50adec12da3' 
  AND token = 'HEm/jMIQ8D7s70nTgXR6gzAKCS6XddJYlFDKN2MulyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}