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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f223ef0f46a44912461a7aae9e198df16216338346d3623f719988d0a11fc61c' 
  AND token = '7wA5BF2IN4/qTH0zXAvh9M9+rBZGWs4iWmMPWdCQuAA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}