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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cfdff88c51552b38d2c02eef7f53e90a0ad36cec8630a37028ea6e4d21a0b69f' 
  AND token = 'xQxQiOsbGy1A5ZggXS9yXiytnNWRc1h7zOXfuUMZAXQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}