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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c2ad7e521fdccfe7858607e092011c6e69b7e417f66fb84e74431927b7dfca' 
  AND token = 'V9q7Z4lAYlqtwC80HM/y+ONuPtAlIW567Cb+5k9uuzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}