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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f59509b2b72c11e8f73fa1359695af36a1a9d397a76c0488d113fce95d0321c0' 
  AND token = 'TvyRD65ujhc0aYw1FhGUvCG+cDkhKMWl4HM2adZjfmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}