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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b424154005fe15d7a4cf0be08a74d955b5d7d188591b9dbfa84c70b52befa3f' 
  AND token = '6JXC3j25gZESQHV3SDxckioL3YbFG3xySTxQtJE/3dA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}