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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8abc6b1a39bab0673cb3541da7a349f853f7e118bcc7f11000416282f770152' 
  AND token = 'x5JPxo+aiU5pLybTSA7jo7CgwM2jGD2mGdd8kFsEx0Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}