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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649c12f4b5684b60368b2499859d39b7a5b33783d6f322f063a1130b20aec1aa' 
  AND token = 'KPdNE6uHASrUy7sGeNUZMFIFIJr66dMEqyyTKOtodJ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}