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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221f575026711cbe243ce277cbf5f95e8d7a6c95265b4b2b21f7613b7e2a720c' 
  AND token = 'SFjlpJMSlzWX2HJ69Dpj1HZ1+2gppmixLEex0o4xSGE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}