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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49956e8102e80e44d84023e29993a03a206ede78a7fff4c63a22e32a2244fc92' 
  AND token = '8D8vvex2/BLvTpF9i7tJMOpY4Qx4VcgvqfywpMPzPKc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}