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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '245121b34c7e3a3ef28c3f5a73f3978f920313c3b56e6f35e377865055acc8b3' 
  AND token = 'bsJwGt3hh2ReAxxTkGsmohAzDbVKvdYf7lKpR/H0CFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}