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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8cf4462621d8fe97e3c3ebcdb0141a6a9da5a17f07868b06f24927e9c1435bd1' 
  AND token = '8kzJy2UdmEzedAQUd+61cne0oBuMgtYBksgCbsSuplY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}