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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '659c0d7889462a28a69428a1f7c2b76fd008a41aea7f025e81a86d981452d3f5' 
  AND token = 'QM8gHdcV/gXt+YFtRr//NXHiismeMYXBQbK0I74YV8E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}