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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01446d2c0b6c30d556f5408bc7fa35ecf350ec9a4a5acf192d2304728e377038' 
  AND token = 'c8tFMDc/NRzsN/QoV/jMoAckCtfQLTBb84tGMSUycdk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}