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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0b41e00ccb3c9e040747c1158af18da453e2d7311d6b532d47526248c2cb151' 
  AND token = 'tYUKDSM7WXi0DSGZfsbAGUPL2IkJRkRpzb7/NPCjbh0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}