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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d7021f3a70e2a6db57859c1a68ca367ead044eb7ca28ca8f4c53c4eccf719d1' 
  AND token = '+LOcmFGHnS8n2ANSEwZrv6Hh8cAr5blfwvUahH0DjS4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}