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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd6336b0282cebb01a73db78a221490cdf5153cb9f692598d4dcb21624a61ab8' 
  AND token = 'QO9hcbvc/QZL7mStXw5ex7Kl2e9yEJ+OcN2jq65zmm8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}