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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21edc04dfa7527293a06ab5008909f0bff16be62fda185f7f6347fbd18114c12' 
  AND token = 'poCBl5iY7TnsFjEk79WfBJXXwa0UkUHHC4xjjVEtoJU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}