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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c53065e20b741765ca47435b4d63c35728f6376918eaec33abaf068f257c5e5' 
  AND token = 'nL0iq3tf7A3tAY+kAeCWMkDTR26fZhd3lQhttH/7Ja0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}