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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52defe352300f8f97d10586fadb8720ebb196c87d3a93fe722696d427bd5edd1' 
  AND token = '+3C0+9ZS3DOmcGeq8NYuaCQaicd+/uzbHCqXuljFZLA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}