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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e8adba11d46a1e3760838adbc0db581488c2c65c4b1a87df035ad58f924ddc6' 
  AND token = 'mrbCDUwKkyOiPr+A7KKo4y2IrGCaNtkb+LF9hNyMSiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}