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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f253e10b39699dad2f5c4a53ec330e8dd80a77990a7ae26250e58425d9efb32c' 
  AND token = '45MtZQIWK1ksAKRoqnclgkiElAS+080HesIm1pBym8I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}