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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22f6146100014566697648fb5ac32efd2017aae97f542e1e726f1c9108b802df' 
  AND token = 'XB3NYY3MxkrmPXpP3Ry2mdIPrPXR5/6ckRe9Z85N2c8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}