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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25298b449af7e01cf9bc5eed2878b2118610da09a026dc34b157484c6b01db32' 
  AND token = 'O8v+ES0HOuCUJml+1g5Phh/4EdPm5eLPCkr8HHTdtAw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00056

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}