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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1780388ad43e47cdcb818fb75ad0bc80cadb804cb0337ff8857c65e80d74b7a6' 
  AND token = 'Z4hKhQW4Zz/gNsy0YsqMbZE/hNt4j/9tXbleSwx1GpI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}