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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d9e02a85d92f60b56fa2b8eb525998564cbd733372c137d0db1e22d3d1363ad' 
  AND token = 'lVhWVvLNUgs6WktLw8tGd2zcpU/zXzlr7GPwrT53kYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}