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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f781d7bf30e2b2472545b35db09c458d9baf62f7eb4da18da2ad80f5ff1df0b' 
  AND token = 'QifxIuzmmVm0MFtu1yHoPgQ/0eIN7yeuz6owjZqXjfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}