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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4a2a31b44d730e8ba5e1acbca6551ac575ea3b9e5107b5d6146bd76c58fd169' 
  AND token = '1UzbDrKr/8n7o0q49LQV9PbtZS6c6X5ctNUO2BpE/Jg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}