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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e159c3f46998df0c1d11b1dad3f93e237b3d182a8429e548ac7ed3f2e910e1e1' 
  AND token = 'qFHX36w2AS9XpOTsR15fun6moXvNrQ+WcB+Ouuo5L2Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}