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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '481cb4d97af704012c112a1794631467561b1410a37bd5217b1c36eb541f67f1' 
  AND token = '1ZcYeCPFBz/bK0e5fQhNV13+r7rGqpxHSRKoy6U0dmY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}