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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f1c1e07189453417e50f3790aa3b5738c2c9bf54a967f7c011bb016773da5a4' 
  AND token = 'eAaTZtTaSRWMCYXwHRU1xMRp4lmwBZf7YR85IfwA6pY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}