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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5422cc21bd47595b456030a6571c2b2fa21b4dd55b281c6d992aed0212a24701' 
  AND token = 'h9pnsw5oDSGZqO9d/DHzhDjXCcgkPTI7d4OlG7hE8oQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}