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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c42c11cfb33c9e51703875402de4b4149507b1329a2f670b6fc48c18ecb8b994' 
  AND token = 'YBBIhxs+SW6iLhhnbpfS0XgxwmfmcJ4liNh6RJUMUWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}