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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66ea0b94ef5d6f2657f25a393941e29e6726debc37171561d19ef2115c648519' 
  AND token = 'elAKYP9MqkQ4L4EcX29UQHZmwDF/CjL8w8C4CmTfnEA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}