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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a016a3d988fc006f645f80a223b749d9ccd633ec65caf0968b21c6c5a1314391' 
  AND token = 'FNep0VM8rgAQ+0NC77rtyVaJ9Ybp4y410h2NcifVGlk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}