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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e25f914aa6d77482b40fbaa48f73dbcc03aa504f91144b85227bfd89f8cfa05' 
  AND token = 'KAgK1ktN0XLQGDB0G6bUb0T3vuvQtSoZwDpNJfc1/Ek=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}