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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fab2f35405bf07e06fd2396ea24b0f727f5bd2ab8d4914b2f924a3d5377979b3' 
  AND token = 'E2TPVK9UoL+vIuRelkZ0GYk2rJ1KmpOBm8XeWeAUzzE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}