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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c27e9babd64f0fa97b7782d96c33960b7e0d6935eb33186ac821ed19f726baa' 
  AND token = 'TWZP1DxhjqkzFcNe00QdZVMmY0pxiUpNITWrdF123LI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}