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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '606a9b105c945dd31c7403027365df878baf2d43fdbb7ebabbadd91b7b479644' 
  AND token = 'JryRQQl/nAmbvxZhh49LRnOlMY1x1YoEiQMGpG54Xws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}