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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a123949c701b0900f70eef2ee27ff944589d1e5588586a82e6648a07a605c27' 
  AND token = '/1bEvIiRmWJbk+CQMGMf6mdqUhwF3qSPtZMKyXmaqGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}